The “Director’s Challenge: Toward a Molecular Classification of Cancer” challenges the cancer research community to demonstrate the power of comprehensive molecular technologies by developing profiles of molecular alterations in human tumors. These “molecular signatures” are intended to redefine tumor classification, moving from morphology-based to molecular-based classification schemes.
The Director’s Challenge investigators are developing strategies for analyzing tumor specimens using technologies including:
Grantees are seeking “molecular signatures” associated with:
The Director’s Challenge investigators in collaboration with the NCI are addressing issues of the management, analysis and public release of the large, complex data sets developed on these projects.
NCI is dedicated to making the information, analytical tools, reagents and protocols developed by the Director’s Challenge Initiative and other NCI activities available to the cancer research community. NCI continues to support the development and applications of new technologies.